Opportunity Information: Apply for W81XWH 20 KCRP IDA
The DoD Kidney Cancer Research Program (KCRP) FY20 Idea Development Award is a competitive research funding opportunity designed to push forward bold, scientifically grounded ideas that can meaningfully accelerate progress toward the program's long-term vision of eliminating kidney cancer. The emphasis is on innovation paired with rigor: proposals need a clear, testable hypothesis supported by a strong scientific rationale and a well thought-out research strategy. Projects should be positioned to make a real difference in kidney cancer research or care, and they must be relevant to active duty Service members, Veterans, other military beneficiaries, and, more broadly, the American public.
A major expectation of this award is that the science is not only creative but also carefully planned and executable. Applications are expected to show deep understanding of kidney cancer biology and clinical challenges, using experimental approaches that may be entirely novel or strongly justified based on prior published work and/or preliminary results. Feasibility is scrutinized: applicants are expected to lay out a realistic research design, identify necessary resources (and document access to them), anticipate potential obstacles, and present backup strategies if the original plan runs into problems. Where appropriate, the proposal should include a statistical analysis plan and power calculations to justify sample sizes and ensure the study can produce interpretable results.
Preliminary data are required for all applications, but they do not have to be generated specifically in kidney cancer. Data can come from the PI's lab, collaborators, or relevant published literature, as long as it supports the rationale and feasibility of the proposed idea. This structure is meant to encourage new directions while still ensuring the work is anchored in evidence rather than speculation. Innovation is treated as a central evaluation feature: reviewers are looking for projects that challenge existing paradigms, introduce new conceptual frameworks, or apply creative approaches with the potential for high payoff. Proposals that are mainly incremental advances over existing work are explicitly discouraged.
Impact is another key decision factor. The program is looking for projects that tackle a central, important problem in kidney cancer research or clinical care and that, if successful, would significantly advance at least one of the FY20 KCRP Areas of Emphasis. In addition, the program highlights the recommendations of the Congressionally mandated Metastatic Cancer Task Force, encouraging applicants to align ideas with those broader metastatic cancer priorities when feasible and within the rules of this announcement, particularly where the work could help speed translational progress for advanced or recurrent disease.
The award is open to two categories of independent investigators serving as Principal Investigator (PI): Established Investigators (EIs) and Early Career Investigators (ECIs). An EI is generally defined as an independent investigator at or above Assistant Professor (or equivalent) who is 10 years or more past their terminal degree, with kidney cancer expertise demonstrated through publications and funding. An ECI is an independent investigator at the Assistant Professor/Instructor/Assistant Research Professor level (or equivalent) who is less than 10 years from the terminal degree at the submission deadline, with certain exclusions allowed for medical residency and family medical leave (but not for postdoctoral time; postdoctoral fellows are not eligible for ECI status). The funding opportunity signals a strong interest in supporting at least one meritorious application led by an ECI PI, and ECIs are reviewed using different personnel criteria to account for career stage.
Because the program treats the team as crucial to success, applicants need to demonstrate meaningful kidney cancer experience either through the PI's background, the assembled research team, or clearly defined collaborations. Collaborations are expected to be documented. For ECIs specifically, the application must include a Career Guide and a Career Development Plan. The Career Guide is required to be at least an Associate Professor (or equivalent) with a proven record of kidney cancer research productivity (publications, patents, and/or funding) and must provide a letter of support. The intent is to pair promising early-stage faculty with experienced mentorship and clear professional development structure while they execute the proposed research.
In terms of what research can be proposed, the announcement supports innovative, high-risk/high-reward and/or preclinical kidney cancer research that is supported by preliminary and/or published data. Two optional focus tracks allow for larger budgets when well justified. The Early Detection Studies Option supports basic or preclinical work aimed at biomarkers, improved imaging, and/or new technologies that could shift the field toward earlier identification of kidney cancer; higher funding can be requested because early detection projects may involve human subjects or human biospecimens and therefore require additional infrastructure. The Population Science and Prevention Studies Option supports population-based, epidemiologic, or public health research that already has substantial supporting evidence and a strong, well-defined path toward clinical translation in kidney cancer; this option also allows higher budgets with compelling justification, and it encourages the use of data and/or biospecimens from active duty Service members and/or Veteran populations.
Research involving human subjects and human anatomical substances is permitted under this mechanism, but clinical trials are not allowed. Awards are made as assistance agreements, meaning they may be issued as either a grant or a cooperative agreement depending on the expected level of DoD involvement during performance. If substantial agency involvement is anticipated (for example, collaboration or intervention in the research), a cooperative agreement may be used; otherwise, a standard grant is more likely. The specific award type and start date are finalized during negotiation.
Budget limits are expressed as anticipated maximum direct costs over the full period of performance. The standard Idea Development Award is capped at $600,000 in direct costs. The Early Detection Studies Option may request up to $650,000 in direct costs. The Population Science and Prevention Studies Option may request up to $2,000,000 in direct costs, reflecting the larger scale and infrastructure often needed for population-level research and biospecimen-based efforts. Overall, the program planned to allocate about $18.1 million to fund approximately 14 awards, with final funding dependent on federal appropriations, the number of submissions, and application quality as determined through scientific peer review and programmatic review. The original application deadline for this FY20 opportunity was September 23, 2020, and awards were planned to be made no later than September 30, 2021, using FY20 funds that were expected to remain available for obligation and use through September 30, 2026.Apply for W81XWH 20 KCRP IDA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Kidney Cancer, Idea Development Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Jun 04, 2020.
- Applicants must submit their applications by Sep 23, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 14 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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